Agenda

2nd Annual Texas Medical Center Antimicrobial Resistance
and Stewardship Conference
BRC Building
January 23-25, 2019

Day 1 – Wednesday, January 23, 2019
Mechanisms of Antibiotic Resistance and Novel Antibiotic Approaches

8:00 – 8:30 Registration

8:30 – 9:15 Opening Key Note Lecture
Plasmids and Antibiotic Resistance: Novel Insights into Bacterial Sex
Alessandra Carattoli, BSc, PhD
Research Director – Istituto Superiore di Sanità

Session 1
Conveners: Barbara Murray, MD and Tim Palzkill, PhD

9:15 – 9:45 Targeting Toxin Production and Toxin Activity as a Novel Non-Antibiotic Therapy for Clostridium difficile Infections
Charles Darkoh, PhD
Associate Professor – UTHealth School of Public Health

9:45 – 10:15 CRISPR and Antibiotic Resistance
David Weiss, PhD
Associate Professor – Emory University

10:15 – 10:30 Break

Session 2
Conveners: Ashok Chopra, PhD and David Greenberg, MD

10:30 – 11:00 Daptomycin Resistance in Enterococci: Beyond liaFSR
Truc T. Tran, PharmD
Assistant Professor – UTHealth Science Center at Houston

11:00 – 11:30 Evobiotics: Resistance to Resistance
Anthony Maresso, PhD
Associate Professor – Baylor College of Medicine

11:30 – 11:45 Selected abstract: Parallel Dissemination of KPC-Producing Klebsiella pneumoniae ST258 and ST307 in Houston, TX
William Shropshire
University of Texas Health Science Center

11:45 – 12:00 Selected abstract: Engineering β-lactamase Inhibitory Protein (BLIP) Variants with Altered Binding Specificity for β-lactamase Antibiotic Resistance Enzymes
Shuo Lu
Baylor College of Medicine

12:00 – 12:45 Rapid Fire Session (Event Space)

12:45 – 2:00 Poster session and lunch (Event Space) Posters 1-25

Session 3
Conveners: Sam Shelburne, MP, PhD and Blake Hanson, PhD

2:00 – 2:30 The Origin of Community-Associated MRSA
Ashley Robinson, PhD
Professor – University of Mississippi

2:30 – 3:00 Double Trouble: Tandem GES β-lactamases in ST309 Pseudomonas aeruginosa
William R. Miller, MD
Assistant Professor – UTHealth Science Center at Houston

3:00 – 3:30 Beta-Lactamase Inhibitors; a Renaissance
Robert Bonomo, MD
Professor of Medicine – Case Western Reserve University

3:30 – 3:45 Break

Session 4
Conveners: Adriana Rosato, PhD and Eric Brown, PhD

3:45 – 4:15 Antibiotic Adjuvants
Gerry Wright, PhD
Professor – McMaster University

4:15 – 4:45 Evolution of Antibiotic Resistance
Yousif Shamoo, PhD
Vice Provost for Research – Rice University

4:45 – 5:00 Selected abstract: The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection
Ravi Marreddy
Institute for Biosciences and Technology, TAMUHSC

5:00 – 5:15 Selected abstract: Phage Loaded Magnetic Nanoparticles to Remove Multidrug Resistant Bacterial Biofilms: A Combined Experimental and Computational Study
Pingfeng Yu
Rice University

Day 2 – Thursday, January 24, 2019
Pharmacology of Antimicrobials, Microbiome and Clinical Impact of Resistance

7:30 – 8:00 Registration

Session 5
Conveners: Tor Savidge, PhD and Samuel L. Aitken, PharmD

8:00 – 8:30  Vancomycin – Current Practice Considerations
Thomas Lodise, PharmD, PhD
Professor – Albany University

8:30 – 9:00 PK/PD Considerations: New β-lactam/β-lactamase Inhibitors
Vincent Tam, PharmD
Professor – University of Houston

9:00 – 9:30 The Development of New Anti-infectives for Drug Resistant Infections
Omonike Olaleye, PhD
Professor of Pharmacology – Texas Southern University

9:30 – 9:45 Break

Session 6
Conveners: Kevin Garey and Diana Panesso, PhD

9:45 – 10:15 Dysbiosis and Restoration of the Intestinal Microbiome
Herbert DuPont, MD
Professor – UTHealth School of Public Health

10:15 – 10:45 The Microbiome Now and Beyond: A Functional Microbiome Perspective of Human Infectious Disease
Tor Savidge, PhD
Associate Professor – Baylor College of Medicine

10:45 – 11:15 The Clinical Microbiology of the 21st Century
Robin Patel, MD
Professor of Microbiology and Medicine – Mayo Clinic, Rochester

11:15 – 11:45 The Antibacterial Resistance Leadership Group – Results, Innovations and Next Steps
Vance Fowler, MD
Professor of Medicine – Duke University

11:45 – 12:00 Selected abstract: LiaX Regulates Daptomycin (DAP) Resistance and is Responsible for the See-saw Effect by Altering Penicillin-binding Protein Localization in Multidrug-resistant Enterococcus faecalis
Ayesah Khan
University of Texas Health Science Center

12:00 – 12:15 Selected abstract: Transmission of Genetically Related, Multidrug Resistant, and Invasive Vancomycin-Resistant Enterococci (VRE) between Patients and Rooms on the Stem Cell Transplant (SCT) and Leukemia (LKM) Units
Lynn El Haddad
MD Anderson Cancer Center

12:15 – 1:00 Rapid Fire Session (Event Space)

1:00 – 2:00 Poster Session and Lunch (Event Space) Posters 26-50, 59

Session 7
Conveners: Julian Hurdle, PhD and Andrew Chou, MD

2:00 – 2:30 Bicarbonate Resensitization of MRSA to Beta-Lactams
Arnold S. Bayer, MD
Distinguished Professor of Medicine – UCLA

2:30 – 3:00 Opening the DOOR: Novel Concepts in Clinical Trial Analyses for Resistance
Scott Evans, PhD
Sr. Research Scientist – George Washington University

3:00 – 3:30 Microbiome Predicts Clinical Outcomes in Cancer Patients
Jessica Galloway-Pena, PhD
Assistant Professor – UT MD Anderson Cancer Center

3:30 – 3:45 Break

Session 8
Conveners: Lynn Zechiedrich, PhD and Trish Perl-DeLisle, MD

3:45 – 4:15 Clinical Aspects of Enterococcal Bacteremia
Jose Munita, MD
Associate Professor – Clinica Alemana, Universidad del Desarrollo

4:15 – 4:45 Mold-resistant Infections
Dimitrios Kontoyiannis, MD
Professor – UT MD Anderson Cancer Center

4:45 – 5:15 NIH Funding for Antimicrobial Resistance
Clayton Huntley, PhD – NIH AMR program
Antimicrobial Resistance Program Officer – NIAID, Bethesda

5:15 – 6:15 A Futuristic View of the Microbiome
Lynn Bry, MD, PhD
Associate Professor – Harvard Medical School

Day 3 – Friday, January 25, 2019
Emerging Strategies for Antibiotic Stewardship to Prevent Resistance

7:30 – 8:00 Registration

Session 9
Conveners: Charlene Offiong,RPh, PharmD and Isaam Raad, MD

8:00 – 8:45 Keynote: One Health Antibiotic Stewardship
Ruth Lynfield, MD
State Epidemiologist and Medical Director – Minnesota Department of Health

8:45 – 9:10 Public Health Policies and Activities for Antibiotic Stewardship
David Hyun, MD
Senior Officer – The Pew Charitable Trusts

9:10 – 9:35 Antibiotic Stewardship: The Joint Commission Perspective
David W. Baker, MD, MPH, FACP
Executive Vice President – The Joint Commission

9:35 – 10:00 Statewide Antimicrobial Stewardship Collaborative
Timothy Jenkins, MD
Associate Professor – University of Colorado

10:00 – 10:15 Break

Session 10
Conveners: Kristi Kuper, PharmD and Robert Atmar, MD

10:15 –10:40 Quick Wins in Antibiotic Stewardship
Shivani Patel, PharmD, BCPS
Clinical Specialist – Memorial Hermann Southwest Hospital

10:40 – 11:05 Doing What’s Best for Our Patients
Antimicrobial Stewardship in the ED
Larissa May, MD
Professor of Emergency Medicine – UC Davis Health

11:05 – 11:30 Antibiotic Stewardship and the Quality Connection
Mike Hill, MD
Medical Director – St. Tammany Parish Hospital, Louisiana

11:30 – 12:00 The Influence of Behavior in Antibiotic Stewardship
Julia Szymczak, PhD
Assistant Professor – University of Pennsylvania

12:00 – 12:45 Rapid Fire Session (Event Space)

12:45 – 1:45 Poster Session and Lunch (Event Space) Posters 51-75

Session 11
Conveners: Barbara Trautner, MD and Will Musick, PharmD

1:45 – 2:10 Leveraging Microbiology in Antibiotic Stewardship
Katherine Perez, PhD
Professor and Chair – Houston Methodist

2:10 – 2:35 Antiviral Resistance Update
Roy F. Chemaly, MD, MPH, FACP, FIDSA
Professor – UT MD Anderson Cancer Center

2:35 – 3:00 Antifungal Resistance Update
Luis Ostrosky-Zeichner, MD
Professor – UTHealth Science Center at Houston

3:00 – 3:25 Antifungal Stewardship in Clinical Practice
Samuel L. Aitken, PharmD, BCPS (AQ-ID)
Clinical Pharmacy Specialist – UT MD Anderson Cancer Center

3:25 Closing remarks